RAD52 variants influence NSCLC risk in the Chinese population in a high altitude area.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) accounts for approximately 80% of diagnosed lung cancer patients. RAD52 has been reported to be associated with the development of squamous cell lung carcinoma. In this study, we assessed the relationships of RAD52 genetic polymorphisms and NSCLC risk among the Chinese population at high altitude.

Methods

Eight single nucleotide polymorphisms (SNPs) of RAD52 were genotyped in the Agena MassARRAY platform among 506 NSCLC patients and 510 healthy controls. We examined the association of RAD52 polymorphisms with NSCLC risk using odds ratios (ORs) and 95% confidence intervals (CIs) via multiple genetic models.

Results

The rs10774474 A allele was related to a decreased risk of NSCLC in a high

SUBMITTER: Li M 

PROVIDER: S-EPMC7223216 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature