Surfactant replacement therapy: from biological basis to current clinical practice.

ABSTRACT: This review summarizes the current knowledge on the physiological action of endogenous and exogenous pulmonary surfactant, the role of different types of animal-derived and synthetic surfactants for RDS therapy, different modes of administration, potential risks and strategies of ventilation, and highlights the most promising aims for future development. Scientists have clarified the physicochemical properties and functions of the different components of surfactant, and part of this successful research is derived from the characterization of genetic diseases affecting surfactant composition or function. Knowledge from functional tests of surfactant action, its immunochemistry, kinetics and homeostasis are important also for improving therapy with animal-derived surfactant preparations and

SUBMITTER: Hentschel R 

PROVIDER: S-EPMC7223236 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature