Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy.

ABSTRACT: Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of various diseases. The therapeutic potential of MSCs is attributed to complex cellular and molecular mechanisms of action including differentiation into multiple cell lineages and regulation of immune responses via immunomodulation. The plasticity of MSCs in immunomodulation allow these cells to exert different immune effects depending on different diseases. Understanding the biology of MSCs and their role in treatment is critical to determine their potential for various therapeutic applications and for the development of MSC-based regenerative medicine. This review summarizes the recent progress of particular mechanisms underlying the tissue regenerative properties and immunomodulatory effects of MSCs. We

SUBMITTER: Fan XL 

PROVIDER: S-EPMC7223321 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature