Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements.

ABSTRACT: The norepinephrine transporter (NET) is a major target for the evaluation of the cardiac sympathetic nerve system in patients with heart failure and Parkinson's disease. It is also used in the therapeutic applications against certain types of neuroendocrine tumors, as exemplified by the clinically used ^123/131I-MIBG as theranostic single-photon emission computed tomography (SPECT) agent. With the development of more advanced positron emission tomography (PET) technology, more radiotracers targeting NET have been reported, with superior temporal and spatial resolutions, along with the possibility of functional and kinetic analysis. More recently, fluorine-18-labelled NET tracers have drawn increasing attentions from researchers, due to their longer radiological half-life relative

SUBMITTER: Chen X 

PROVIDER: S-EPMC7223405 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature