Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial.

ABSTRACT:

Background

Nitric oxide (NO) plays an important role in normal postnatal transition. Our aims were to determine whether adding inhaled NO (iNO) decreases supplemental oxygen exposure in preterm infants requiring positive pressure ventilation (PPV) during resuscitation and to study iNO effects on heart rate (HR), oxygen saturation (SpO₂), and need for intubation during the first 20 min of life.

Methods

This was a pilot, double-blind, randomized, placebo-controlled trial. Infants 25 0/7-31 6/7 weeks' gestational age requiring PPV with supplemental oxygen during resuscitation were enrolled. PPV was initiated with either oxygen (FiO₂-0.30) + iNO at 20 ppm (iNO group) or oxygen (FiO₂-0.30) + nitrogen (placebo group). Oxygen was titrated targeting

SUBMITTER: Sekar K 

PROVIDER: S-EPMC7223624 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature