Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response.

ABSTRACT:

Background

An immune active cancer phenotype typified by a T helper 1 (Th-1) immune response has been associated with increased responsiveness to immunotherapy and favorable prognosis in some but not all cancer types. The reason of this differential prognostic connotation remains unknown.

Methods

To explore the contextual prognostic value of cancer immune phenotypes, we applied a multimodal pan-cancer analysis among 31 different histologies (9282 patients), encompassing immune and oncogenic transcriptomic analysis, mutational and neoantigen load and copy number variations.

Results

We demonstrated that the favorable prognostic connotation conferred by the presence of a Th-1 immune response was abolished in tumors displaying specific tumor-cell intrinsic attributes such

SUBMITTER: Roelands J 

PROVIDER: S-EPMC7223637 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature