A physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection.

ABSTRACT: Mechanical ventilation is used to sustain respiratory function in patients with acute respiratory failure. To aid clinicians in consistently selecting lung- and diaphragm-protective ventilation settings, a physiology-based decision support system is needed. To form the foundation of such a system, a comprehensive physiological model which captures the dynamics of ventilation has been developed. The Lung and Diaphragm Protective Ventilation (LDPV) model centers around respiratory drive and incorporates respiratory system mechanics, ventilator mechanics, and blood acid-base balance. The model uses patient-specific parameters as inputs and outputs predictions of a patient's transpulmonary and esophageal driving pressures (outputs most clinically relevant to lung and diaphragm safety), as well

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7224026 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature