Magnitude and timing of major white matter tract maturation from infancy through adolescence with NODDI.

ABSTRACT: White matter maturation is a nonlinear and heterogeneous phenomenon characterized by axonal packing, increased axon caliber, and a prolonged period of myelination. While current in vivo diffusion MRI (dMRI) methods, like diffusion tensor imaging (DTI), have successfully characterized the gross structure of major white matter tracts, these measures lack the specificity required to unravel the distinct processes that contribute to microstructural development. Neurite orientation dispersion and density imaging (NODDI) is a dMRI approach that probes tissue compartments and provides biologically meaningful measures that quantify neurite density index (NDI) and orientation dispersion index (ODI). The purpose of this study was to characterize the magnitude and timing of major white matter tract m

SUBMITTER: Lynch KM 

PROVIDER: S-EPMC7224237 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature