Vitamin D and Vulnerable Carotid Plaque.

ABSTRACT:

Background and purpose

MR imaging-detected carotid intraplaque hemorrhage indicates vulnerable plaque with high stroke risk. Angiotensin II stimulates intraplaque hemorrhage in animal models, and the angiotensin system is highly regulated by vitamin D. Our purpose was to determine whether low vitamin D levels predict carotid intraplaque hemorrhage in humans.

Materials and methods

In this cross-sectional study, 65 patients with carotid disease underwent carotid MR imaging and blood draw. Systemic clinical confounders and local lumen imaging markers were recorded. To determine the association of low vitamin D levels with MR imaging detected intraplaque hemorrhage, we performed multivariable Poisson regression by using generalized estimating equations to account for up to 2 car

SUBMITTER: McNally JS 

PROVIDER: S-EPMC7224245 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature