Evidence for rate-dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells.

ABSTRACT: Recent studies have revealed that global extrinsic noise arising from stochasticity in the intracellular biochemical environment plays a critical role in heterogeneous cell physiologies. However, it remains largely unclear how such extrinsic noise dynamically influences downstream reactions and whether it could be neutralized by cellular reactions. Here, using fluorescent protein (FP) maturation as a model biochemical reaction, we explored how cellular reactions might combat global extrinsic noise in mammalian cells. We developed a novel single-cell assay to systematically quantify the maturation rate and the associated noise for over a dozen FPs. By exploiting the variation in the maturation rate for different FPs, we inferred that global extrinsic noise could be temporally filtered by ma

SUBMITTER: Wu J 

PROVIDER: S-EPMC7224485 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature