COMBSecretomics: A pragmatic methodological framework for higher-order drug combination analysis using secretomics.

ABSTRACT: Multi drug treatments are increasingly used in the clinic to combat complex and co-occurring diseases. However, most drug combination discovery efforts today are mainly focused on anticancer therapy and rarely examine the potential of using more than two drugs simultaneously. Moreover, there is currently no reported methodology for performing second- and higher-order drug combination analysis of secretomic patterns, meaning protein concentration profiles released by the cells. Here, we introduce COMBSecretomics (https://github.com/EffieChantzi/COMBSecretomics.git), the first pragmatic methodological framework designed to search exhaustively for second- and higher-order mixtures of candidate treatments that can modify, or even reverse malfunctioning secretomic patterns of human cells. This

SUBMITTER: Chantzi E 

PROVIDER: S-EPMC7224510 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature