Radioimmunotherapy of methicillin-resistant Staphylococcus aureus in planktonic state and biofilms.

ABSTRACT: BACKGROUND:Implant associated infections such as periprosthetic joint infections are difficult to treat as the bacteria form a biofilm on the prosthetic material. This biofilm complicates surgical and antibiotic treatment. With rising antibiotic resistance, alternative treatment options are needed to treat these infections in the future. The aim of this article is to provide proof-of-principle data required for further development of radioimmunotherapy for non-invasive treatment of implant associated infections. METHODS:Planktonic cells and biofilms of Methicillin-resistant staphylococcus aureus are grown and treated with radioimmunotherapy. The monoclonal antibodies used, target wall teichoic acids that are cell and biofilm specific. Three different radionuclides in different doses were u

SUBMITTER: van Dijk B 

PROVIDER: S-EPMC7224548 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature