A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels.

ABSTRACT: Mechanical interactions between flowing and coagulated blood (thrombus) are crucial in dictating the deformation and remodeling of a thrombus after its formation in hemostasis. We propose a fully-Eulerian, three-dimensional, phase-field model of thrombus that is calibrated with existing in vitro experimental data. This phase-field model considers spatial variations in permeability and material properties within a single unified mathematical framework derived from an energy perspective, thereby allowing us to study effects of thrombus microstructure and properties on its deformation and possible release of emboli under different hemodynamic conditions. Moreover, we combine this proposed thrombus model with a particle-based model which simulates the initiation of the thrombus. The volume fra

SUBMITTER: Zheng X 

PROVIDER: S-EPMC7224566 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature