The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.

ABSTRACT:

Aim

Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic stressors. The aim of this work was to examine the interaction between the sympathetic and motor nervous system, the involvement of the sympathetic nervous system (SNS) in neuromuscular junction (NMJ) presynaptic motor function, the stability of postsynaptic molecular organization, and the skeletal muscle composition and function.

Methods

Since muscle weakness is a symptom of diseases characterized by autonomic dysfunction, we studied the impact of regional sympathetic ablation on muscle motor innervation by using transcriptome analysis, retrograde tracing of the sympathetic outflow to the skeletal muscle, confocal and

SUBMITTER: Rodrigues ACZ 

PROVIDER: S-EPMC7224611 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature