Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid.

ABSTRACT:

Purpose

Acute exacerbation (AE) is an important domain of asthma management and may be related with ineffective response to corticosteroid. This study aimed to find mechanisms of AE using genome-wide gene expression profiles of blood cells from asthmatics and its perturbation by in vitro dexamethasone (Dex)-treatment.

Methods

We utilized lymphoblastoid B cells from 107 childhood asthmatics and peripheral blood mononuclear cells from 29 adult asthmatics who were treated with inhaled corticosteroids. We searched for a preserved co-expression gene module significantly associated with the AE rate in both cohorts and measured expression changes of genes belong to this module after Dex-treatment.

Results

We identified a preserved module composed of 77 genes. Among th

SUBMITTER: Kang MG 

PROVIDER: S-EPMC7224997 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature