Resting-State SEEG May Help Localize Epileptogenic Brain Regions.

ABSTRACT:

Background

Stereotactic electroencephalography (SEEG) is a minimally invasive neurosurgical method to localize epileptogenic brain regions in epilepsy but requires days in the hospital with interventions to trigger several seizures.

Objective

To make initial progress in the development of network analysis methods to identify epileptogenic brain regions using brief, resting-state SEEG data segments, without requiring seizure recordings.

Methods

In a cohort of 15 adult focal epilepsy patients undergoing SEEG, we evaluated functional connectivity (alpha-band imaginary coherence) across sampled regions using brief (2 min) resting-state data segments. Bootstrapped logistic regression was used to generate a model to predict epileptogenicity of individual regions.

Results

SUBMITTER: Goodale SE 

PROVIDER: S-EPMC7225010 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature