RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury <i>in vivo</i>.

ABSTRACT: Understanding the molecular mechanisms that regulate secondary cell death after acute central nervous system (CNS) injury is critical for the development of effective neuroprotective drugs. Previous research has shown that neurotoxic processes including excitotoxicity, oxidative stress and neuroinflammation can cause secondary cell death. Nevertheless, clinical trials targeting these processes have been largely unsuccessful, suggesting that the signalling pathways underlying secondary cell death remain incompletely understood. Due to their suitability for live imaging and their amenability to genetic and pharmacological manipulation, larval zebrafish provide an ideal platform for studying the regulation of secondary cell death in vivo Here, we use RNA-seq gene expression profiling a

SUBMITTER: Herzog C 

PROVIDER: S-EPMC7225090 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature