SKA1/2/3 serves as a biomarker for poor prognosis in human lung adenocarcinoma.

ABSTRACT:

Background

Spindle and kinetochore associated complex subunit 1/2/3 (SKA1/2/3), which stabilized spindle microtubules attaching to kinetochore (KT) in the middle stage of mitosis, were dysregulated, and closely related to prognosis in several malignant tumors. Nevertheless, the potential clinical value of SKA1/2/3, especially in terms of prognosis and development of NSCLC, had not been fully elucidated.

Methods

ONCOMINE, GEPIA, UALCAN, TCGA, STRING and other databases were used to analyze the expression of SKA1/2/3 in patients with lung adenocarcinoma (LUAD) and its clinical value, and to explore the possible regulatory mechanism of SKA in the occurrence and development of LUAD.

Results

In patients with LUAD, SKA1/2/3 mRNA expression level was significantly up-regulat

SUBMITTER: Chen C 

PROVIDER: S-EPMC7225159 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature