Virucidal Efficacy of Olanexidine Gluconate as a Hand Antiseptic Against Human Norovirus.

ABSTRACT: Human noroviruses are the major cause of non-bacterial acute gastroenteritis worldwide. Since no therapeutic agent has been proven to prevent human norovirus infection yet, preventive healthcare interventions to block the infection routes play an important role in infection control. One of the possible infection routes of human noroviruses are through contaminated hands, but no hand antiseptics have been proven effective. Olanexidine gluconate is a new biguanide compound that has already been approved for sale as an antiseptic for the surgical field in Japan. A new hand antiseptic was developed using olanexidine gluconate in this study, and its virucidal efficacy against human noroviruses was evaluated using modified RT-qPCR that can account for genome derived from intact viruses using RNa

SUBMITTER: Imai K 

PROVIDER: S-EPMC7225205 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature