Expansion of Host Regulatory T Cells by Secreted Products of the Tapeworm Echinococcus multilocularis.

ABSTRACT:

Background

Alveolar echinococcosis (AE), caused by the metacestode larval stage of the fox-tapeworm Echinococcus multilocularis, is a chronic zoonosis associated with significant modulation of the host immune response. A role of regulatory T-cells (Treg) in generating an immunosuppressive environment around the metacestode during chronic disease has been reported, but the molecular mechanisms of Treg induction by E. multilocularis, particularly parasite immunoregulatory factors involved, remain elusive so far.

Methodology/principal findings

We herein demonstrate that excretory/secretory (E/S) products of the E. multilocularis metacestode promote the formation of Foxp3⁺ Treg from CD4⁺ T-cells in vitro in a TGF-β-dependent mann

SUBMITTER: Nono JK 

PROVIDER: S-EPMC7225322 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature