Plasma microRNA expression levels in HIV-1-positive patients receiving antiretroviral therapy.

ABSTRACT: MicroRNAs (miRNAs/miRs) may serve as therapeutic agents or targets in diseases in which the expression of proteins plays an important role. The aim of the present study was to compare the expression levels of specific miRNAs, as well as their correlation with markers of response to antiretroviral (ARV) therapy, in patients with human immunodeficiency virus type 1 (HIV-1) infection with and without resistance to highly active antiretroviral therapy (HAART).

Methods

miRNA assays were performed on plasma samples obtained from 20 HIV-1-positive patients. A total of ten patients were divided into two groups: HAART-responsive and HAART-resistant (n=5 per group). Commercial arrays were subsequently used to identify 84 miRNAs. A total of three differentially expressed miRNAs were selected a

SUBMITTER: Marquez-Pedroza J 

PROVIDER: S-EPMC7225415 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature