Transcriptome analysis and functional identification of adipose-derived mesenchymal stem cells in secondary lymphedema.

ABSTRACT:

Background

Secondary lymphedema is a common condition that affects patients with malignant tumors. Conservative treatments fail to provide lasting relief because they do not address the underlying pathological accumulation of excessive fat. Our aim is to clarify the molecular mechanisms of abnormal adipogenic differentiation in lymphedema adipose tissue.

Methods

We compared the proliferation and adipogenesis potential of adipose-derived mesenchymal stem cells (ASCs) from the lymphedema adipose tissue from liposuction specimens of 10 patients with extremity lymphedema with that of ASCs from adipose tissue from the normal upper abdomen of the same patients. Transcriptome analysis were performed to identify the differences between the two kinds of ASCs. Cyclin-dependent kinase

SUBMITTER: Xiang Q 

PROVIDER: S-EPMC7225476 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature