Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study.

ABSTRACT:

Background

Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans.

Methods

Associations between prediagnostic plasma levels of 17 primary, secondary, and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations.

Results

SUBMITTER: Kuhn T 

PROVIDER: S-EPMC7225675 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature