Personalized Medicine-Current and Emerging Predictive and Prognostic Biomarkers in Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide and is heterogeneous both morphologically and molecularly. In an era of personalized medicine, the greatest challenge is to predict individual response to therapy and distinguish patients likely to be cured with surgical resection of tumors and systemic therapy from those resistant or non-responsive to treatment. Patients would avoid futile treatments, including clinical trial regimes and ultimately this would prevent under- and over-treatment and reduce unnecessary adverse side effects. In this review, the potential of specific biomarkers will be explored to address two key questions-1) Can the prognosis of patients that will fare well or poorly be determined beyond currently recognized prognostic indicators? and

SUBMITTER: Koulis C 

PROVIDER: S-EPMC7225926 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature