Novel Apoptotic Mediators Identified by Conservation of Vertebrate Caspase Targets.

ABSTRACT: Caspases are proteases conserved throughout Metazoans and responsible for initiating and executing the apoptotic program. Currently, there are over 1800 known apoptotic caspase substrates, many of them known regulators of cell proliferation and death, which makes them attractive therapeutic targets. However, most caspase substrates are by-standers, and identifying novel apoptotic mediators amongst all caspase substrates remains an unmet need. Here, we conducted an in silico search for significant apoptotic caspase targets across different species within the Vertebrata subphylum, using different criteria of conservation combined with structural features of cleavage sites. We observed that P1 aspartate is highly conserved while the cleavage sites are extensively variable and found that cleav

SUBMITTER: Gubina N 

PROVIDER: S-EPMC7225963 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature