Alginate Formulations: Current Developments in the Race for Hydrogel-Based Cardiac Regeneration.

ABSTRACT: Cardiovascular diseases, including myocardial infarction (MI), represent the main worldwide cause of mortality and morbidity. In this scenario, to contrast the irreversible damages following MI, cardiac regeneration has emerged as a novel and promising solution for in situ cellular regeneration, preserving cell behavior and tissue cytoarchitecture. Among the huge variety of natural, synthetic, and hybrid compounds used for tissue regeneration, alginate emerged as a good candidate for cellular preservation and delivery, becoming one of the first biomaterial tested in pre-clinical research and clinical trials concerning cardiovascular diseases. Although promising results have been obtained, recellularization and revascularization of the infarcted area present still major limitations. Therefo

SUBMITTER: Cattelan G 

PROVIDER: S-EPMC7226066 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature