Structural Insight into the Mechanism of N-Linked Glycosylation by Oligosaccharyltransferase.

ABSTRACT: Asparagine-linked glycosylation, also known as N-linked glycosylation is an essential and highly conserved post-translational protein modification that occurs in all three domains of life. This modification is essential for specific molecular recognition, protein folding, sorting in the endoplasmic reticulum, cell-cell communication, and stability. Defects in N-linked glycosylation results in a class of inherited diseases known as congenital disorders of glycosylation (CDG). N-linked glycosylation occurs in the endoplasmic reticulum (ER) lumen by a membrane associated enzyme complex called the oligosaccharyltransferase (OST). In the central step of this reaction, an oligosaccharide group is transferred from a lipid-linked dolichol pyrophosphate donor to the acceptor substrate, the side cha

SUBMITTER: Mohanty S 

PROVIDER: S-EPMC7226087 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature