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Metabolic Regulation of Myeloid-Derived Suppressor Cell Function in Cancer.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are a group of immunosuppressive cells that play crucial roles in promoting tumor growth and protecting tumors from immune recognition in tumor-bearing mice and cancer patients. Recently, it has been shown that the metabolic activity of MDSCs plays an important role in the regulation of their inhibitory function, especially in the processes of tumor occurrence and development. The MDSC metabolism, such as glycolysis, fatty acid oxidation and amino acid metabolism, is rewired in the tumor microenvironment (TME), which enhances the immunosuppressive activity, resulting in effector T cell apoptosis and suppressive cell proliferation. Herein, we summarized the recent progress in the metabolic reprogramming and immunosuppressive function of MDSCs during tumorigenesis.

SUBMITTER: Wang Y

PROVIDER: S-EPMC7226088 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Metabolic Regulation of Myeloid-Derived Suppressor Cell Function in Cancer.

Wang Yufei Y Jia Anna A Bi Yujing Y Wang Yuexin Y Liu Guangwei G

Cells 20200418 4

Myeloid-derived suppressor cells (MDSCs) are a group of immunosuppressive cells that play crucial roles in promoting tumor growth and protecting tumors from immune recognition in tumor-bearing mice and cancer patients. Recently, it has been shown that the metabolic activity of MDSCs plays an important role in the regulation of their inhibitory function, especially in the processes of tumor occurrence and development. The MDSC metabolism, such as glycolysis, fatty acid oxidation and amino acid me ...[more]

PMID: 32325683

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