Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma.

ABSTRACT: Medulloblastoma is the most common and malignant pediatric brain tumor in childhood. It originates from dysregulation of cerebellar development, due to an excessive proliferation of cerebellar granule neuron precursor cells (CGNPs). The underlying molecular mechanisms, except for the role of SHH and WNT pathways, remain largely unknown. ERBB4 is a tyrosine kinase receptor whose activity in cancer is tissue dependent. In this study, we characterized the role of ERBB4 during cerebellum development and medulloblastoma progression paying particular interests to its role in CGNPs and medulloblastoma stem cells (MBSCs). Our results show that ERBB4 is expressed in the CGNPs during cerebellum development where it plays a critical role in migration, apoptosis and differentiation. Similarly, it is e

SUBMITTER: Aldaregia J 

PROVIDER: S-EPMC7226104 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature