The Prognostic Value of the Detection of Microbial Translocation in the Blood of Colorectal Cancer Patients.

ABSTRACT: Dysbiosis has been associated with various diseases and is of major health importance. Dysbiosis leads to microbial translocation, which is the passage of microorganisms, their fragments, or their metabolites from the intestinal lumen into the blood circulation and other sites. The aim of the study was to determine whether microbial translocation occurs in stage II/III-IV colorectal cancer (CRC) patients. The aim was also to evaluate the usefulness of blood PCR for diagnosis of such translocation and correlate the presence of toll-like receptor/vitamin D receptor (TLR/VDR) gene polymorphisms with microbial DNA fragments detected in the blood of CRC patients. Three hundred and ninety-seven CRC patients enrolled in the study. Peripheral blood DNA was analyzed using PCR for the amplification

SUBMITTER: Messaritakis I 

PROVIDER: S-EPMC7226464 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature