STAT4 sequence variant and elevated gene expression are associated with type 1 diabetes in Polish children.

ABSTRACT:

Introduction

Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic β cells, resulting from coincident genetic predisposition and some environmental triggers. Signal transducer and activator of transcription 4 (STAT4) gene encodes a transcription factor, which promotes Th1 cell differentiation, interferon γ production, and development of Th17 cells. Polymorphisms of STAT4 are associated with several autoimmune conditions, while studies in T1D provided inconsistent results. This analysis was designed to investigate the association of STAT4 rs7574865 with T1D in Polish children and to assess STAT4 expression in newly diagnosed subjects.

Material and methods

Rs7574865 was genotyped in 656 T1D children and 782 healthy individuals. STAT4 mRNA expression was a

SUBMITTER: Fichna M 

PROVIDER: S-EPMC7226553 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature