Current Strategies and Future Perspectives for Precision Medicine in Pancreatic Cancer.

ABSTRACT: Current standard-of-care for patients with pancreatic ductal adenocarcinoma (PDAC) focusses on chemotherapeutic regimens and pancreatic cancer surgery. However, limited treatment options, late diagnosis in advanced tumor stages and the aggressive behavior of PDAC contribute to the high mortality of the disease. Consequently, there is an urgent need of precision medicine for pancreatic cancer patients. All over the world, numerous initiatives started in recent years to translate novel scientific discoveries into prospective clinical trials. One major approach pursues the stratification of PDAC patients according the tumor transcriptome to predict treatment response. Other strategies concentrate on genomic alterations and the identification of individualized targeted therapies. Further exper

SUBMITTER: Regel I 

PROVIDER: S-EPMC7226595 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature