Biosynthesis of acetylacetone inspired by its biodegradation.

ABSTRACT:

Background

Acetylacetone is a commercially bulk chemical with diverse applications. However, the traditional manufacturing methods suffer from many drawbacks such as multiple steps, harsh conditions, low yield, and environmental problems, which hamper further applications of petrochemical-based acetylacetone. Compared to conventional chemical methods, biosynthetic methods possess advantages such as being eco-friendly, and having mild conditions, high selectivity and low potential costs. It is urgent to develop biosynthetic route for acetylacetone to avoid the present problems.

Results

The biosynthetic pathway of acetylacetone was constructed by reversing its biodegradation route, and the acetylacetone was successfully produced by engineered Escherichia coli (E. col

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7226712 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature