M1 macrophage features in severe Plasmodium falciparum malaria patients with pulmonary oedema.

ABSTRACT:

Background

Pulmonary oedema (PE) is a serious complication of Plasmodium falciparum malaria which can lead to acute lung injury in severe cases. Lung macrophages are activated during malaria infection due to a complex host-immune response. The molecular basis for macrophage polarization is still unclear but understanding the predominant subtypes could lead to new therapeutic strategies where the diseases present with lung involvement. The present study was designed to study the polarization of lung macrophages, as M1 or M2 macrophages, in the lungs of severe P. falciparum malaria patients, with and without evidence of PE.

Methods

Lung tissue samples, taken from patients who died from severe P. falciparum malaria, were categorized into severe malaria with PE and without PE (n

SUBMITTER: Klinkhamhom A 

PROVIDER: S-EPMC7226720 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature