Large Animal Models of Inherited Retinal Degenerations: A Review.

ABSTRACT: Studies utilizing large animal models of inherited retinal degeneration (IRD) have proven important in not only the development of translational therapeutic approaches, but also in improving our understanding of disease mechanisms. The dog is the predominant species utilized because spontaneous IRD is common in the canine pet population. Cats are also a source of spontaneous IRDs. Other large animal models with spontaneous IRDs include sheep, horses and non-human primates (NHP). The pig has also proven valuable due to the ease in which transgenic animals can be generated and work is ongoing to produce engineered models of other large animal species including NHP. These large animal models offer important advantages over the widely used laboratory rodent models. The globe size and dimension

SUBMITTER: Winkler PA 

PROVIDER: S-EPMC7226744 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature