NeuroHeal Treatment Alleviates Neuropathic Pain and Enhances Sensory Axon Regeneration.

ABSTRACT: Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phenomena. Incipient or aberrant sensory axon regeneration is related to abnormal unpleasant sensations, such as hyperalgesia or allodynia. We recently have discovered NeuroHeal, a combination of two repurposed drugs; Acamprosate and Ribavirin. NeuroHeal is a neuroprotective agent that also enhances motor axon regeneration after PNI. In this work, we investigated its effect on sensory fiber regeneration and PNI-induced painful sensations in a rat model of spare nerve injury and ne

SUBMITTER: Romeo-Guitart D 

PROVIDER: S-EPMC7226810 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature