In vivo and in silico evaluation of antinociceptive activities of seed extract from the Holarrhena antidysenterica plant.

ABSTRACT: The objective of the study was to investigate the analgesic activity of seeds extracted from the Holarrhena antidysenterica plant (Family: Apocynaceae). The seeds of H. antidysenterica were extracted with pure ethanol and administered to the experimental Swiss albino mice at three different doses (50, 100, and 150 mg/kg body weight) in pain models. Peripheral analgesic activity was evaluated using the acetic acid-induced writhing test, and heat-induced (hot plate and tail immersion test) pain models were applied for central anti-nociceptive activity evaluation. Formalin induced licking test was applied to evaluate both peripheral and central anti-nociceptive activity on mice. Computational studies were performed by Schrödinger Maestro v10.1 for molecular docking and the SwissADME online se

SUBMITTER: Bhuiyan MMR 

PROVIDER: S-EPMC7226892 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature