Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions.

ABSTRACT: The major defense system against microbial pathogens in vertebrates is the adaptive immune response and represents an effective mechanism in cancer surveillance. T cells represent an essential component of this complex system. They can recognize myriads of antigens as short peptides (p) originated from the intracellular degradation of foreign proteins presented by major histocompatibility complex (MHC) proteins. The clonotypic T-cell antigen receptor (TCR) is specialized in recognizing pMHC and triggering T cells immune response. It is still unclear how TCR engagement to pMHC is translated into the intracellular signal that initiates T-cell immune response. Some work has suggested the possibility that pMHC binding induces in the TCR conformational changes transmitted to its companion CD3 s

SUBMITTER: Alba J 

PROVIDER: S-EPMC7226950 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature