Ontology highlight
ABSTRACT:
SUBMITTER: Appelman MD
PROVIDER: S-EPMC7226988 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Appelman Monique D MD Robin Marion J D MJD Vogels Esther W M EWM Wolzak Christie C Vos Winnie G WG Vos Harmjan R HR Van Es Robert M RM Burgering Boudewijn M T BMT Van de Graaf Stan F J SFJ
Cells 20200416 4
The sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the basolateral membrane of hepatocytes, where it mediates the uptake of conjugated bile acids and forms the hepatocyte entry receptor for the hepatitis B and D virus. Here, we aimed to identify novel protein-protein interactions that could play a role in the regulation of NTCP. To this end, NTCP was precipitated from HA-tagged hNTCP-expressing HepG2 cells, and chloride channel CLIC-like 1 (CLCC1) and stomatin were identif ...[more]