Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4.

ABSTRACT: Endoglin is a membrane glycoprotein primarily expressed by the vascular endothelium and involved in cardiovascular diseases. Upon the proteolytic processing of the membrane-bound protein, a circulating form of endoglin (soluble endoglin, sEng) can be released, and high levels of sEng have been observed in several endothelial-related pathological conditions, where it appears to contribute to endothelial dysfunction. Preeclampsia is a multisystem disorder of high prevalence in pregnant women characterized by the onset of high blood pressure and associated with increased levels of sEng. Although a pathogenic role for sEng involving hypertension has been reported in several animal models of preeclampsia, the exact molecular mechanisms implicated remain to be identified. To search for sEng-indu

SUBMITTER: Gallardo-Vara E 

PROVIDER: S-EPMC7226995 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature