Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy.

ABSTRACT: Cathepsins (CTSs) are ubiquitously expressed proteases normally found in the endolysosomal compartment where they mediate protein degradation and turnover. However, CTSs are also found in the cytoplasm, nucleus, and extracellular matrix where they actively participate in cell signaling, protein processing, and trafficking through the plasma and nuclear membranes and between intracellular organelles. Dysregulation in CTS expression and/or activity disrupts cellular homeostasis, thus contributing to many human diseases, including inflammatory and cardiovascular diseases, neurodegenerative disorders, diabetes, obesity, cancer, kidney dysfunction, and others. This review aimed to highlight the involvement of CTSs in inherited lysosomal storage disorders, with a primary focus to the emerging ev

SUBMITTER: De Pasquale V 

PROVIDER: S-EPMC7227001 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature