PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer.

ABSTRACT:

Background

PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate that PPFIA1 is an important promoter of migration and invasion in breast cancer. This study aims to evaluate the utility of PPFIA1 expression in the luminal breast cancer as a prognostic marker to predict the response to endocrine therapy.

Methods

Large, well-characterised cohorts of primary luminal breast cancer patients with long-term follow-up was assessed for the clinical impact of PPFIA1 expression at the transcriptomic and proteomic levels. Prognostic significance of PPFIA1 and its relationship with clinical outcome and benefit of endocrine therapy were a

SUBMITTER: Alfarsi LH 

PROVIDER: S-EPMC7227113 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature