Effect of dimethyl fumarate on lymphocyte subsets in patients with relapsing multiple sclerosis.

ABSTRACT:

Background

In patients treated with dimethyl fumarate, absolute lymphocyte count decline typically occurs during the first year and then plateaus; early drops have been associated with the development of severe prolonged lymphopenia.

Objective

We investigated the effect of dimethyl fumarate on absolute lymphocyte counts and CD4+/CD8+ T cells in patients with relapsing-remitting multiple sclerosis treated with dimethyl fumarate in routine practice.

Methods

Lymphocyte data were collected via medical chart abstraction. Primary endpoint: change from baseline in absolute lymphocyte count and CD4+/CD8+ counts at 6-month intervals following dimethyl fumarate initiation.

Results

Charts of 483 patients were abstracted and 476 patients included in the analysis. Mean base

SUBMITTER: Buckle G 

PROVIDER: S-EPMC7227148 | biostudies-literature | 2020 Apr-Jun

REPOSITORIES: biostudies-literature