Tropomyosin 1 genetically constrains in vitro hematopoiesis.

ABSTRACT:

Background

Identifying causal variants and genes from human genetic studies of hematopoietic traits is important to enumerate basic regulatory mechanisms underlying these traits, and could ultimately augment translational efforts to generate platelets and/or red blood cells in vitro. To identify putative causal genes from these data, we performed computational modeling using available genome-wide association datasets for platelet and red blood cell traits.

Results

Our model identified a joint collection of genomic features enriched at established trait associations and plausible candidate variants. Additional studies associating variation at these loci with change in gene expression highlighted Tropomyosin 1 (TPM1) among our top-ranked candidate genes. CRISPR/Cas9-mediated T

SUBMITTER: Thom CS 

PROVIDER: S-EPMC7227211 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature