Clinicopathological and prognostic significance of nestin expression in patients with breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Nestin has been revealed to promote tumorigenesis, progression, metastasis, and angiogenesis of breast cancer. Although the prognostic and clinicopathological impact of nestin expression on breast cancer patients has been assessed in several independent studies, their results remained conflicting. Therefore, we performed this meta-analysis to elucidate the prognostic and clinicopathological association of nestin expression with breast cancer.

Methods

A comprehensive literature search was performed in the electronic databases PubMed, EMBASE, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), and the Wangfang Data. The statistical analysis was conducted using Stata 15.0 and Review Manager 5.3.

Results

A total of 15 studies w

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7227264 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature