Application of the matched nested case-control design to the secondary analysis of trial data.

ABSTRACT:

Background

A nested case-control study is an efficient design that can be embedded within an existing cohort study or randomised trial. It has a number of advantages compared to the conventional case-control design, and has the potential to answer important research questions using untapped prospectively collected data.

Methods

We demonstrate the utility of the matched nested case-control design by applying it to a secondary analysis of the Abnormal Doppler Enteral Prescription Trial. We investigated the role of milk feed type and changes in milk feed type in the development of necrotising enterocolitis in a group of 398 high risk growth-restricted preterm infants.

Results

Using matching, we were able to generate a comparable sample of controls selected from the same

SUBMITTER: Partlett C 

PROVIDER: S-EPMC7227268 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature