Understanding the genetic basis of congenital insensitivity to pain.

ABSTRACT:

Introduction or background

Congenital insensitivity to pain (CIP) is caused by extremely rare Mendelian genetic disorders. CIP individuals demonstrate the unexpectedly severe consequences of painlessness. Although only a small number of causative conditions and genes are known, most have led to profound insights into human nociception. CIP gene discovery is catalyzing the manufacture of completely new classes of analgesics, and these are needed as alternatives to synthetic highly potent opioids.

Sources of data

Pubmed.gov peer-reviewed journal articles and reviews.

Areas of agreement

The importance of nerve growth factor-tropomyosin receptor kinase A (NGF-TRKA) signalling for nociceptor genesis and subsequent pain sensing.New analgesics can be generated from knowledge

SUBMITTER: Drissi I 

PROVIDER: S-EPMC7227775 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature