Strong T_H1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.

ABSTRACT: Activated CD4 T cells are a major target of HIV infection. Results from the STEP HIV vaccine trial highlighted a potential role for total activated CD4 T cells in promoting HIV acquisition. However, the influence of vaccine insert-specific CD4 T cell responses on HIV acquisition is not known. Here, using the data obtained from four macaque studies, we show that the DNA prime/modified vaccinia Ankara boost vaccine induced interferon γ (IFNγ⁺) CD4 T cells [T helper 1 (T_H1) cells] rapidly migrate to multiple tissues including colon, cervix, and vaginal mucosa. These mucosal T_H1 cells persisted at higher frequencies and expressed higher density of CCR5, a viral coreceptor, compared to cells in blood. After intravaginal or intrarectal simian immunodeficiency vir

SUBMITTER: Chamcha V 

PROVIDER: S-EPMC7227795 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature