Effects of Glycyrrhetic Acid on Human Chronic Myelogenous Leukemia Cells.

ABSTRACT:

Objectives

Chronic myelogenous leukemia (CML) is a type of blood cancer that is initially treated with imatinib (first Abl kinase inhibitor). However, some patients with CML develop imatinib resistance. Several new generation drugs have been developed, but do not overcome this problem. Glycyrrhetic acid (GA) is a plant-derived pentacyclic triterpenoid that exhibits multiple pharmacological properties for the treatment of cancers. The current study aimed to investigate the effects of GA on the K562 cell line (Bcr-Abl positive leukemia).

Materials and methods

The MTT cell proliferation assay was employed to evaluate the cytotoxic effect of GA compared with imatinib (positive control) against leukemia and normal blood cells. For detection of cell death, an apoptotic/necrotic/he

SUBMITTER: Ciftci H 

PROVIDER: S-EPMC7227864 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature