Optimization of Thiazolidone Scaffolds Using Pocket Modeling for Development of Potential Secretory System Inhibitors of Mycobacterium tuberculosis.

ABSTRACT:

Objectives

Mycobacterium tuberculosis is the causative organism of tuberculosis, which is the most lethal disease after cancer in the current decade. The development of multidrug and broadly drug-resistant strains is making the problem of tuberculosis more and more critical. In the last 40 years, only one molecule has been added to the treatment regimen. Generally, drug design and development programs target proteins whose function is known to be essential to the bacterial cell. M. tuberculosis possesses specialized protein export systems like the SecA2 export pathway and ESX pathways.

Materials and methods

In the present communication, rational development of an antimycobacterial agent's targeting protein export system was carried out by integrating pocket mod

SUBMITTER: Khare SV 

PROVIDER: S-EPMC7227957 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature